Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs
|Project Period:||3/2008 - 12/2012|
|Investor:||Ministry of Education, Youth and Sports of the CR|
|Field:||CE - Biochemistry (C - Chemistry)|
FR - Pharmacology and pharmaceutical chemistry (F - Medicine)
|Keywords:||lectins; pathogens; biomolecular interactions; X-ray structure; docking; molecular modelling|
The goals and expected results of the proposed project are directed to the field of studies on lectins from pathogens that are involved in the host cell recognition and binding, which may further result in invasion. In the first period of the research, we will focus our attention on bacterial lectins, mostly those from opportunistic pathogens, which are dangerous mainly for immunocompromised patients. In the second period, we will extend our studies also on viruses. Our goals will be not only to characterize the above interaction from the structure and function point of view, but mainly to design molecules that will “inhibit” these lectins and will, therefore, exhibit pharmacological effects. Within this direction, the main tool will be theoretical methods, essentially docking and sophisticated database search in libraries of existing compounds. Also in silico methods development within this direction will be included.