DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands
|Original title:||DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands|
|Authors:||Jaroslav Malina, Ctirad Hofr, Lucciana Maresca, Giovanni Natile, Viktor Brabec|
|Type:||Article in Periodical|
Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously.