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DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands

Basic information
Original title:DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands
Authors:Jaroslav Malina, Ctirad Hofr, Lucciana Maresca, Giovanni Natile, Viktor Brabec
Further information
Citation:MALINA, Jaroslav, Ctirad HOFR, Lucciana MARESCA, Giovanni NATILE a Viktor BRABEC. DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands. Biophysical Journal, New York, USA: Rockefeller University, 2000, roč. 2000, č. 78, s. 2008-2021. ISSN 0006-3465.Export BibTeX
@article{328871,
author = {Malina, Jaroslav and Hofr, Ctirad and Maresca, Lucciana and Natile, Giovanni and Brabec, Viktor},
article_location = {New York, USA},
article_number = {78},
language = {eng},
issn = {0006-3465},
journal = {Biophysical Journal},
title = {DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands},
volume = {2000},
year = {2000}
}
Original language:English
Field:Biophysics
Type:Article in Periodical

Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously.