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IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen

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Original title:IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen
Authors:Zdeněk Adam, Marta Krejčí, Luděk Pour, Josef Feit, Tomáš Büchler, Roman Hájek
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Original language:English
Field:Oncology and hematology
Type:Article in Periodical
Keywords:IgA pemphigus;bortezomib; rituximab; monoclonal gammopathy

Monoclonal gammopathy-associated IgA pemphigus is a debilitating skin disorder with inconsistent response to treatment. A 61-year-old woman with IgA pemphigus and monoclonal gammopathy of unknown significance had been treated with bortezomib, cyclophosphamide and dexamethasone regimen, which resulted in complete and durable remission of multiple myeloma and IgA pemphigus. This suggests that bortezomib-based therapy is useful for the treatment of the rare dermatologic disorder associated with IgA gammopathy.

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