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Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels

Basic information
Original title:Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels
Authors:Jan Juřica, Ondřej Zendulka, Richard Barteček, Alexandra Žourková, Eva Flodrová, Jana Zrůstová, Alexandra Šulcová
Further information
Citation:JUŘICA, Jan, Ondřej ZENDULKA, Richard BARTEČEK, Alexandra ŽOURKOVÁ, Eva FLODROVÁ, Jana ZRŮSTOVÁ and Alexandra ŠULCOVÁ. Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels (Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels). In 9.th International ISSX meeting. 2010.Export BibTeX
@proceedings{902425,
author = {Juřica, Jan and Zendulka, Ondřej and Barteček, Richard and Žourková, Alexandra and Flodrová, Eva and Zrůstová, Jana and Šulcová, Alexandra},
booktitle = {9.th International ISSX meeting},
keywords = {CYP2D6, metabolic ratio, dextromehorphan},
language = {eng},
title = {Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels},
year = {2010}
}
Original language:English
Field:Pharmacology and pharmaceutical chemistry
Type:Conference abstract
Keywords:CYP2D6, metabolic ratio, dextromehorphan

The results of investigation of correlation of serum and urine dextromethorphan/dextrorphan metabolic ratio in CYP2D6 phenotyping were presented. Based on genetic analysis and values of MR, cutt off values (MRdem/dor) for separating extensive, poor and intermediate metabolizers were also identfied.

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