Informace o publikaci
Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | International Journal of Colorectal Disease |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://link.springer.com/article/10.1007%2Fs00384-012-1461-3 |
| Doi | http://dx.doi.org/10.1007/s00384-012-1461-3 |
| Obor | Onkologie a hematologie |
| Klíčová slova | miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration |
| Popis | MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects. |
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