Detail publikace
Identification and functional screening of microRNAs highly deregulated in colorectal cancer
| Základní údaje | |
|---|---|
| Originální název: | Identification and functional screening of microRNAs highly deregulated in colorectal cancer |
| Název česky: | Identifikace a funkční screening miRNA vysoce deregulovaných u CRC |
| Autoři: | Petra Faltejsková, Marek Svoboda, Klára Šrůtová, Jitka Mlčochová, Andrej Bešše, Jana Nekvindová, Lenka Radová, Pavel Fabian, Kateřina Slabá, Igor Kiss, Rostislav Vyzula, Ondřej Slabý |
| Další údaje | |
|---|---|
| Citace: | FALTEJSKOVÁ, Petra, Marek SVOBODA, Klára ŠRŮTOVÁ, Jitka
MLČOCHOVÁ, Andrej BEŠŠE, Jana NEKVINDOVÁ, Lenka RADOVÁ, Pavel
FABIAN, Kateřina SLABÁ, Igor KISS, Rostislav VYZULA a Ondřej
SLABÝ. Identification and functional screening of microRNAs
highly deregulated in colorectal cancer. Journal of Cellular
and Molecular Medicine, Malden, USA: WILEY -BLACKWELL, 2012,
roč. 16, č. 11, s. 2655-2666. ISSN 1582-1838.
doi:10.1111/j.1582-4934.2012.01579.x.Export BibTeX@article{979332, author = {Faltejsková, Petra and Svoboda, Marek and Šrůtová, Klára and Mlčochová, Jitka and Bešše, Andrej and Nekvindová, Jana and Radová, Lenka and Fabian, Pavel and Slabá, Kateřina and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej}, article_location = {Malden, USA}, article_number = {11}, doi = {http://dx.doi.org/10.1111/j.1582 -4934.2012.01579.x},keywords = {apoptosis; colorectal cancer; expression profilin; microRNA; migration}, language = {eng}, issn = {1582 -1838},journal = {Journal of Cellular and Molecular Medicine}, title = {Identification and functional screening of microRNAs highly deregulated in colorectal cancer}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22469014}, volume = {16}, year = {2012} } |
| Originální jazyk: | angličtina |
| Obor: | Onkologie a hematologie |
| WWW: |  http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01579.x/pdf, http://www.ncbi.nlm.nih.gov/pubmed/22469014 |
| Druh: | Článek v odborném periodiku |
| Klíčová slova: | apoptosis; colorectal cancer; expression profilin; microRNA; migration |
The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.
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