Project information
Metabolic symbiosis between cancer cells and cancer-associated fibroblasts in head and neck cancer
- Project Identification
- GA21-06873S
- Project Period
- 1/2021 - 12/2023
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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University Hospital Prague - Motol
- Responsible person prof. MUDr. Jan Betka, DrSc., FCMA
Head and neck squamous cell carcinoma (HNSCC) represents the sixth leading cancer by incidence worldwide. The prognosis of HNSCC is based on the TNM staging system, which ultimately results in the same treatment for different HNSCC tumors. This heterogeneity may lie in distinct metabolic profiles of individual HNSCC tumors. Many types of cancer exhibit metabolic symbiosis between tumor cells and cells of the surrounding stroma, mainly cancer-associated fibroblasts (CAFs). This process involves transport of catabolites from CAFs to adjacent cancer cells by various transporters, such as monocarboxylic acid transporters (MCTs), which allows cancer cells to produce ATP, stimulate proliferation and reduce apoptosis. In this project, we want to further study the metabolic symbiosis between the cancer cells and surrounding stromal CAFs. Furthermore, we would like to investigate the metabolic profiles of distinct compartments within the HNSCC stroma with an effort to find potential prognostic markers and therapeutic targets of HNSCC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 6
2023
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Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles
Cell Communication and Signaling, year: 2023, volume: 21, edition: 1, DOI
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Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, year: 2023, volume: 1878, edition: 5, DOI
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Engine shutdown: migrastatic strategies and prevention of metastases
Trends in Cancer, year: 2023, volume: 9, edition: 4, DOI
2022
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Advances in Cancer Metabolism and Tumour Microenvironment
Year: 2022, type: Article in Periodical (without peer review)
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Metabolic tricks of cancer cells
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, year: 2022, volume: 1877, edition: 3, DOI
2021
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Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers
Molecular Cancer, year: 2021, volume: 20, edition: 1, DOI