CD36- and GPR120-mediated Ca2+ Signaling in Human Taste Bud Cells Mediates Differential Responses to Fatty Acids and is Altered in Obese Mice

• Authors: OZDENER Mehmet Hakan; SUBRAMANIAM Selvakumar; SUNDARESAN Sinju; ŠERÝ Omar; HASHIMOTO Toshihiro; ASAKAWA Yoshinori; BESNARD Philippe; ABUMRAD Nada A.; KHAN Naim Akhtar
• Year of publication: 2014
• Type: Article in Periodical
• Magazine / Source: Gastroenterology
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1053/j.gastro.2014.01.006
• Field: Physiology
• Keywords: Taste; human; Serotonin; Linoleic acid; GLP-1; Lipids
• Description: It is important to increase our understanding of gustatory detection of dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca2+ signaling in fungiform taste bud cells (TBC). CD36 and GPR120 have non-overlapping roles in TBC signaling during oro-gustatory perception of dietary lipids; these are differentially regulated by obesity.

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