Publication details
Diagnostika vrozených poruch imunity
| Title in English | Diagnostics of primary imunodeficiencies |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Early diagnosis of immunodeficiency makes possible early definitive therapy and avoids the complications of pretreatment infections. B-cell defects constitute the majority of primary immunodeficiencies. All are characterized by the reduction in or absence of immunoglobulins and/or specific antimicrobial antibodies. T-cell immunodeficiency defects become apparent as combined T- and B-cell deficiencies. Therefore, implementation of TRECs and KRECs into the newborn screening from dried blood spot will increase the preventive approach to early immunodeficiency diagnostics. Infants undergoing transplantation in the first 3 months of life have a much higher rate of survival than those undergoing transplantation later. |