Publication details

Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts

Authors

MARVANOVÁ Pavlína PADRTOVÁ Tereza PEKÁREK Tomáš BRUS Jiří CZERNEK Jiří MOKRÝ Petr HUMPA Otakar ORAVEC Michal JAMPILEK Josef

Year of publication 2016
Type Article in Periodical
Magazine / Source Molecules
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.mdpi.com/1420-3049/21/6/707/htm
Doi http://dx.doi.org/10.3390/molecules21060707
Field Organic chemistry
Keywords arylcarbonyloxyaminopropanols; phenylpiperazines; synthesis; CP/MASNMR spectroscopy; IR spectroscopy; principle components analysis
Description Five new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates were designed and synthesized as potential dual antihypertensive agents. The compounds were prepared as free bases and subsequently transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring of hydrochloride salts was determined by means of C-13-CP/MAS and N-15-CP/MAS NMR and IR spectroscopy. Using these solid-state analytical techniques, it was found that both nitrogen atoms were protonated when excess hydrogen chloride was used for preparation of salts. On the other hand, when the equimolar amount of hydrogen chloride was used, piperazine nitrogen substituted by aryl was protonated.
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