Publication details
Efficient synthesis of alpha-substituted-alpha-arylmethyl phosphonates using trichloroacetimidate C-C coupling method
| Authors | |
|---|---|
| Year of publication | 2018 |
| Type | Article in Periodical |
| Magazine / Source | Tetrahedron |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.tet.2018.02.033 |
| Keywords | 1-AMINOPHOSPHONATES; HYDROXYPHOSPHONATES; ACTIVATION; INHIBITORS; RENIN |
| Description | A simple convenient protocol for the synthesis of di-Et alpha,alpha-diaryl methylphosphonate derivs. 5a-f, 6b-f, 7a-f and 8a-f, di-Et alpha-alkenyl alpha-aryl methylphosphonates 9a-d and 10a-d and alpha-(oxoalkyl) alpha-aryl methylphosphonate 11a-d and 12a-d is described. Trichloroacetimidates 3a-d were treated with activated arenes, styrene, allyltrimethylsilane or silylenol ethers C-nucleophiles in the presence TMSOTf to afford the desired products in good yields and short reaction time. |