Publication details
A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Molecules |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.mdpi.com/1420-3049/27/6/1894 |
| Doi | http://dx.doi.org/10.3390/molecules27061894 |
| Keywords | helquat-like compound; RNA-dependent RNA-polymerase; SARS-CoV-2; Flaviruses; antiviral agents |
| Description | Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible. |