Publication details
The effects of posttranslational modifications on function of the Bcl-2 protein
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Bcl-2; apoptosis; cell differentiation; phosphorylation |
| Description | BM2 monoblasts overexpressing Bcl-2 exhibit low viability, condensed chromatin, nuclear fragmentation and DNA fragmentation. Our results suggest that the Bcl-2 protein undergoing post-translational modification by phosphorylation cannot interact with its protein partners thus loosing its capability to suppress apoptosis. |
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