Publication details
Protein p53 zastavuje proliferaci a indukuje diferenciaci v-myb transformovaných monoblastů
| Title in English | p53 protein blocks proliferation and induces differentiation of v-myb-transformed monoblasts |
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| Authors | |
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | p53; differentiation; proliferation; cell cycle; apoptosis |
| Description | We expressed human p53 in avian monoblasts BM2. We showed that in spite of low level of structural homology of human and avian p53 proteins (53%) the human protein is capable of performing at least some of its functions: it blocked proliferation at G2 phase of the cell cycle and induced differentiation to monocytes. In contrast, we did not proved apoptosis-inducing function of human o53 in avian cells. These results document that even significant inter-species differencies tolerate functions of important regulators involved in control of cellular proliferation and differentiation. |
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