Publication details
Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Cellular Signalling |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.cellsig.2008.10.006 |
| Field | Genetics and molecular biology |
| Keywords | fibroblast growth factor; cartilage; STAT1; STAT3; chondrocyte; cytokine; inhibition |
| Description | Activation of FGFR3 leads to attenutation of cartilage growth. We evidence that FGF stimulus leads to accumulation of STAT1, 3, 5, 6 both in chondrocyte model and murine limb explant cultures. Despite this accummulation, STAT 1, and 3 signaling pathways are impaired by FGF. FGF increases also expression of CIS, SOCS1, and SOCS3, inhibitors of IL6 receptor signaling and thus may contribute to the growth-inhibitory effect of FGFR3 signaling in cartilage. |
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