Detection and treatment of molecular relapse in acute myeloid leukemia with RUNXa, CBFB, MLL gene translocations, or NPMI mutation. Frequent quantitative monitoring of molecular markers in different compartments and correlation with WT1 gene expression.

• Authors: DOUBEK Michael; PALÁSEK Ivo; POSPÍŠIL Z.; STRUNCOVÁ S.; DVOŘÁKOVÁ Dana; BORSKÝ M.; KLABUSAY Martin; BRYCHTOVÁ Y.; KREJČÍ Marta; MAYER Jiří
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Annals of Hematology
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: ACUTE LYMPHOBLASTIC-LEUKEMIA; FUSION TRANSCRIPTS; PROGNOSTIC VALUE
• Description: Frequent quantitative monitoring of fusion transcripts is useful for reliably predicting hematological relapse in AML patients. Treatment for molecular relapse of AML can be successful.

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