Publication details
Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Molecular and Biochemical Parasitology |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Trichomonas; initiator binding protein; transcription; protozoa |
| Description | This study focuses on the detailed characterization of the only transcription factor identified in the human pathogen Trichomonas vaginalis, the IBP39 protein. Here we show the nuclear localization of IBP39. In addition, we map the DNA binding domain. It resides near the N-terminus of the protein, between amino acids 45 and 71. The residues 66-70 (KMKKK) are critical for DNA binding. This is the first DNA binding domain to be mapped in the only transcription factor in this parasite to date. |