Publication details
Distinct Roles of TRAMP complexes in yeast RNA Metabolism
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| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | The scientific programme for this Oxford EMBO workshop started with gene transcription, how the chromatin template is made ready for transcription and how the end of the gene is connected to its beginning. This transcription focus will then lead into how processing of the initial pre-mRNA is coupled to transcription, both splicing, but more importantly 3 end processing of: histone, polyA+ mRNAs, small stable RNAs (snRNA and snoRNA) and cryptic unstable RNAs (CUTs). Following nuclear export, mRNA translation is also intimately coupled to the appropriate structure of its 3 end, be this the polyA tail or a hairpin as in histone mRNA. The final critical stage in gene expression is the regulation of mRNA turn over, again closely connected to the integrity of the polyA tail. Superimposed on this whole process of gene expression is a surveillance process that acts at all stages. |