Biomarker discovery in low grade breast cancer: A proteomics based approach

• Authors: BOUCHAL Pavel; MUDROCHOVÁ Monika; ROUMELIOTIS Theodoros; HERNYCHOVÁ Lenka; HRSTKA Roman; GARBIS Spiros D.; NENUTIL Rudolf; VOJTĚŠEK Bořivoj
• Year of publication: 2010
• Type: Conference abstract
• MU Faculty or unit: Faculty of Science
• Description: Traditional prognostic markers of low-grade breast cancer are currently not sufficient for precise risk-group discrimination. Our effort was thus focused on biomarker discovery in this tumor group. Three proteomics approaches were involved in complex protein analysis of tissue lysates: SELDI-TOF MS, iTRAQ-2DLC-MS/MS and 2-D SDS-PAGE. Differentially expressed proteins belong to several functional groups related to breast cancer biology and are presented and discussed on the poster.

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