Triple-negativní karcinom prsu: analýza souboru pacientek diagnostikovaných a/nebo léčených v Masarykově onkologickém ústavu v letech 2004 až 2009

• Title in English: Triple-negative breast cancer: analysis of patients diagnosed and/or treated at the Masaryk Memorial Cancer Institute between 2004 and 2009.
• Authors: SVOBODA Marek; NAVRÁTIL Jiří; FABIAN Pavel; PALÁCOVÁ Markéta; GOMBOŠOVÁ Jana; SLÁMOVÁ L.; PRINC Denis; SYPTÁKOVÁ Blažena; KUDLÁČEK Aleš; BÍLEK Ondřej; POSPÍŠIL P.; KAZDA Tomáš; GRELL Peter; POPRACH Alexandr; SELINGEROVÁ Iveta; NENUTIL Rudolf; JURÁČEK Jaroslav; HÉŽOVÁ Renata; SLABÝ Ondřej; VYZULA Rostislav
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Klinická onkologie
• Field: Oncology and hematology
• Keywords: triple-negative breast cancer; epidemiology; cytokeratin 5/6; Ki-67 protein; chemotherapy
• Description: Triple-negative breast cancer (TNBC) represents a heterogeneous group of breast cancers that do not express ER-alfa, PgR and Her-2 receptors. Generally, these tumors are aggressive and more common in younger women, in which an association of TNBC with mutations in the BRCA1 gene was documented. The aim of our study was to create a representative group of patients with TNBC, which could be analyzed and the data gathered to build basic epidemiological, molecular and clinical characteristics of Czech patients with TNBC.