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Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

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Original title:Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
Authors:Petra Faltejsková, Andrej Bešše, Sabina Ševčíková, Lenka Kubiczková, Marek Svoboda, Jan Šmarda, Igor Kiss, Rostislav Vyzula, Ondřej Slabý
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Original language:English
Field:Oncology and hematology
WWW:link to a new windowhttp://link.springer.com/article/10.1007%2Fs00384-012-1461-3
Type:Article in Periodical
Keywords:miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration

MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

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