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Identification and functional screening of microRNAs highly deregulated in colorectal cancer

Basic information
Original title:Identification and functional screening of microRNAs highly deregulated in colorectal cancer
Authors:Petra Faltejsková, Marek Svoboda, Klára Šrůtová, Jitka Mlčochová, Andrej Bešše, Jana Nekvindová, Lenka Radová, Pavel Fabian, Kateřina Slabá, Igor Kiss, Rostislav Vyzula, Ondřej Slabý
Further information
Citation:FALTEJSKOVÁ, Petra, Marek SVOBODA, Klára ŠRŮTOVÁ, Jitka MLČOCHOVÁ, Andrej BEŠŠE, Jana NEKVINDOVÁ, Lenka RADOVÁ, Pavel FABIAN, Kateřina SLABÁ, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Identification and functional screening of microRNAs highly deregulated in colorectal cancer. Journal of Cellular and Molecular Medicine, Malden, USA: WILEY-BLACKWELL, 2012, vol. 16, No 11, p. 2655-2666. ISSN 1582-1838. doi:10.1111/j.1582-4934.2012.01579.x.Export BibTeX
@article{979332,
author = {Faltejsková, Petra and Svoboda, Marek and Šrůtová, Klára and Mlčochová, Jitka and Bešše, Andrej and Nekvindová, Jana and Radová, Lenka and Fabian, Pavel and Slabá, Kateřina and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
article_location = {Malden, USA},
article_number = {11},
doi = {http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x},
keywords = {apoptosis; colorectal cancer; expression profilin; microRNA; migration},
language = {eng},
issn = {1582-1838},
journal = {Journal of Cellular and Molecular Medicine},
title = {Identification and functional screening of microRNAs highly deregulated in colorectal cancer},
url = {http://www.ncbi.nlm.nih.gov/pubmed/22469014},
volume = {16},
year = {2012}
}
Original language:English
Field:Oncology and hematology
WWW:link to a new windowhttp://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01579.x/pdf, link to a new windowhttp://www.ncbi.nlm.nih.gov/pubmed/22469014
Type:Article in Periodical
Keywords:apoptosis; colorectal cancer; expression profilin; microRNA; migration

The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.

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