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Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer

Basic information
Original title:Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer
Authors:Jiří Šána, Simona Hankeová, Marek Svoboda, Igor Kiss, Rostislav Vyzula, Ondřej Slabý
Further information
Citation:ŠÁNA, Jiří, Simona HANKEOVÁ, Marek SVOBODA, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer. Oncology, Basel: Karger, 2012, vol. 82, No 2, p. 114-118. ISSN 0030-2414. doi:10.1159/000336479.Export BibTeX
@article{984236,
author = {Šána, Jiří and Hankeová, Simona and Svoboda, Marek and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
article_location = {Basel},
article_number = {2},
doi = {http://dx.doi.org/10.1159/000336479},
keywords = {Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388},
language = {eng},
issn = {0030-2414},
journal = {Oncology},
title = {Expression Levels of Transcribed Ultraconserved Regions uc.73 and uc.388 Are Altered in Colorectal Cancer},
url = {http://www.karger.com/Article/Fulltext/336479},
volume = {82},
year = {2012}
}
Original language:English
Field:Oncology and hematology
WWW:link to a new windowhttp://www.karger.com/Article/Fulltext/336479
Type:Article in Periodical
Keywords:Colorectal cancer; Non-coding RNAs; Transcribed ultraconserved regions; uc.73; uc.388

The development of colorectal cancer (CRC) is characterized by multiple genetic alterations. Transcribed ultraconserved regions (T-UCRs) are a subset of 481 sequenc es longer than 200 bp, which are absolutely conserved between orthologous regions of human, rat and mouse genomes, and are actively transcribed. It has recently been proven in cancer systems that differentially expressed T-UCRs could alter the functional characteristics of malignant cells. Genome-wide profiling revealed that T-UCRs have distinct signatures in human leukemia and carcinoma.

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