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Clinical Outcomes of Patients with Nonseminomatous Germ Cell Tumours and Negative Postchemotherapy Positron Emission Tomography

Basic information
Original title:Clinical Outcomes of Patients with Nonseminomatous Germ Cell Tumours and Negative Postchemotherapy Positron Emission Tomography
Authors:Tomáš Büchler, Kateřina Simonová, Pavel Fencl, Jiří Jarkovský, Jitka Abrahámová
Further information
Citation:BÜCHLER, Tomáš, Kateřina SIMONOVÁ, Pavel FENCL, Jiří JARKOVSKÝ and Jitka ABRAHÁMOVÁ. Clinical Outcomes of Patients with Nonseminomatous Germ Cell Tumours and Negative Postchemotherapy Positron Emission Tomography. Cancer Investigation, LONDON: INFORMA HEALTHCARE, 2012, vol. 30, No 6, p. 487-492. ISSN 0735-7907. doi:10.3109/07357907.2012.679347.Export BibTeX
@article{987427,
author = {Büchler, Tomáš and Simonová, Kateřina and Fencl, Pavel and Jarkovský, Jiří and Abrahámová, Jitka},
article_location = {LONDON},
article_number = {6},
doi = {http://dx.doi.org/10.3109/07357907.2012.679347},
keywords = {Positron emission tomography; Germ cell tumour; Testicular cancer; Diagnosis; Relapse},
language = {eng},
issn = {0735-7907},
journal = {Cancer Investigation},
title = {Clinical Outcomes of Patients with Nonseminomatous Germ Cell Tumours and Negative Postchemotherapy Positron Emission Tomography},
volume = {30},
year = {2012}
}
Original language:English
Field:Oncology and hematology
Type:Article in Periodical
Keywords:Positron emission tomography; Germ cell tumour; Testicular cancer; Diagnosis; Relapse

Univariate and multivariate analyses were carried out to identify factors associated with the failure of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) to correctly predict relapse-free survival in patients with nonseminomatous germ cell tumours. Ninety-three patients with negative postchemotherapy FDG-PET scan were analyzed in the retrospective study. The FDG-PET result was validated by long-term follow-up and, in some patients, by resection of the residual tumour mass. The negative predictive value of FDG-PET was 81.7%. Higher tumour marker levels and nodal stage at diagnosis, presence of residual mass, and teratoma or teratocarcinoma in the primary histology were associated with FDG-PET failure.

 
 
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