Project details


The influence of infection on esophageal variceal bleeding and the role of early administration of oral antibiotics in the treatment of such haemorhage

Project Identification:NK6661
Project Period:1/2001 - 1/2003
Investor:link to a new windowMinistry of Health of the CR
MU Faculty/Unit:
Faculty of Medicine
Cooperating Organization:
link to a new windowUniversity Hospital Brno-Bohunice
Responsible Person:Prof. MUDr. Jan Lata, CSc.
Field:FE - Other specializations of internal medicine (F - Medicine)

Acute bleeding is frequent and often fatal complication of liver cirrhosis. The factor influence the occurence of rupture and consequent bleeding are portal pressure, size of varices and Child-Pough classification. The role of infection as a trigger function is not quite clear as well as the role of infection in the course of the therapy. Antibiotics are generally recommended but it is not clear what antibiotics and how to give them. The aim of our study is 1. to determine tre occurrence of infection in patients with liver cirrhosis and acute variceal bleeding 2. to evaluate if administration of oral antibiotics can improve the prognosis of clinical course of the bleeding.