Informace o publikaci

Epidermal Growth Factor Receptor Gene Amplification in Patients with Advanced-stage NSCLC

Autoři	FIALA Ondrej PESEK Milos FINEK Jindrich MINARIK Marek BENESOVA Lucie SOREJS Ondrej SVATON Martin BORTLÍČEK Zbyněk KUCERA Radek TOPOLCAN Ondrej
Rok publikování	2016
Druh	Článek v odborném periodiku
Časopis / Zdroj	Anticancer Research
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Obor	Onkologie a hematologie
Klíčová slova	Non-small cell lung cancer; epidermal growth factor gene; gene amplification; tyrosine kinase inhibitors
Popis	Background: Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) represent novel, effective tools in the management of advanced-stage non-small cell lung cancer (NSCLC). We aimed to evaluate the incidence and predictive role of EGFR gene amplification in patients with advanced-stage NSCLC treated with EGFR-TKIs. Patients and Methods: The study included 290 patients with advanced-stage (IIIB or IV) NSCLC. Multiplex ligation-dependent probe amplification (MLPA) and polymerase chain reaction (PCR) were used for detection of EGFR gene amplification and EGFR mutations, respectively. Results: EGFR amplification was detected in 26 (9.0%) patients. EGFR amplification was found more frequently in patients harboring the EGFR mutation (p<0.001). No significant corelation between EGFR gene amplification and survival was observed. Conclusion: EGFR gene amplification is associated with EGFR gene mutation. EGFR gene amplification is not a feasible predictive biomarker for treatment with EGFR-TKIs in patients with advanced-stage NSCLC.