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Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer

Basic information
Original title:Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer
Authors:Pavel Smilek, Ladislav Dušek, Karel Veselý, Jan Rottenberg, Rom Kostřica
Further information
Citation:SMILEK, Pavel, Ladislav DUŠEK, Karel VESELÝ, Jan ROTTENBERG and Rom KOSTŘICA. Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer (Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer). Neoplasma, Bratislava, 2005, vol. 52, No 3, p. 199-207. ISSN 0028-2685.Export BibTeX
@article{571020,
author = {Smilek, Pavel and Dušek, Ladislav and Veselý, Karel and Rottenberg, Jan and Kostřica, Rom},
article_location = {Bratislava},
article_number = {3},
keywords = {Head & neck cancer risk prognosis mitotic/apoptotic index DNA cytometry},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Prognostic significance of mitotic and apoptotic index and the DNA cytometry in head and neck cancer},
volume = {52},
year = {2005}
}
Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:Head & neck cancer risk prognosis mitotic/apoptotic index DNA cytometry

This study was conducted to analyze prognostic significance of mitotic and apoptotic index and the DNA flow cytometric analysis of HNSCC to the recurrence-free survival time and to the overall survival. The analysis was carried out with a set of 56 patients suffering from carcinoma of the pharynx and supraglottis. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event: a ratio S phase cell fraction /G2M cell fraction was found to be the key prognostic factor (p < 0.01). Early risk events are associated with increased mitotic activity, decreased apoptic rate, decreased S phase cell fraction and significantly increased G2/M fraction.

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