Detail publikace
Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
| Základní údaje | |
|---|---|
| Originální název: | Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases |
| Autoři: | Richard Salzman, Kateřina Kaňková, Lukáš Pácal, Josef Tomandl, Kateřina Šírová, Rom Kostřica |
| Další údaje | |
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| Citace: | SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL,
Kateřina ŠÍROVÁ a Rom KOSTŘICA. Increased activity of superoxid
dismutase in advanced stages of head and neck squamous cell
carcinoma with locoregional metastases. Neoplasma, Blarislava,
Slovakia: Slovak Academy of Sciences, 2007, roč. 54, č. 4, s.
321 -325. ISSN 0028-2685.Export BibTeX@article{725573, author = {Salzman, Richard and Kaňková, Kateřina and Pácal, Lukáš and Tomandl, Josef and Šírová, Kateřina and Kostřica, Rom}, article_location = {Blarislava, Slovakia}, article_number = {4}, keywords = {antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase}, language = {eng}, issn = {0028 -2685},journal = {Neoplasma}, title = {Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases}, volume = {54}, year = {2007} } |
| Originální jazyk: | angličtina |
| Obor: | ORL, oftalmologie, stomatologie |
| Druh: | Článek v odborném periodiku |
| Klíčová slova: | antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase |
Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.
Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.
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