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Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Basic information
Original title:Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
Authors:Richard Salzman, Kateřina Kaňková, Lukáš Pácal, Josef Tomandl, Kateřina Šírová, Rom Kostřica
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Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

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