Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
|Original title:||Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases|
|Authors:||Richard Salzman, Kateřina Kaňková, Lukáš Pácal, Josef Tomandl, Kateřina Šírová, Rom Kostřica|
|Field:||ORL, ophthalmology, stomatology|
|Type:||Article in Periodical|
|Keywords:||antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase|
Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.