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Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Basic information
Original title:Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
Authors:Richard Salzman, Kateřina Kaňková, Lukáš Pácal, Josef Tomandl, Kateřina Šírová, Rom Kostřica
Further information
Citation:SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL, Kateřina ŠÍROVÁ and Rom KOSTŘICA. Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases (Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases). Neoplasma, Blarislava, Slovakia: Slovak Academy of Sciences, 2007, vol. 54, No 4, p. 321-325. ISSN 0028-2685.Export BibTeX
@article{725573,
author = {Salzman, Richard and Kaňková, Kateřina and Pácal, Lukáš and Tomandl, Josef and Šírová, Kateřina and Kostřica, Rom},
article_location = {Blarislava, Slovakia},
article_number = {4},
keywords = {antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases},
volume = {54},
year = {2007}
}
Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

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