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Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Basic information
Original title:Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases
Authors:Richard Salzman, Kateřina Kaňková, Lukáš Pácal, Josef Tomandl, Kateřina Šírová, Rom Kostřica
Further information
Citation:SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL, Kateřina ŠÍROVÁ a Rom KOSTŘICA. Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases. Neoplasma, Blarislava, Slovakia: Slovak Academy of Sciences, 2007, roč. 54, č. 4, s. 321-325. ISSN 0028-2685.Export BibTeX
@article{725573,
author = {Salzman, Richard and Kaňková, Kateřina and Pácal, Lukáš and Tomandl, Josef and Šírová, Kateřina and Kostřica, Rom},
article_location = {Blarislava, Slovakia},
article_number = {4},
keywords = {antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases},
volume = {54},
year = {2007}
}
Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

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