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Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers

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Original title:Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers
Authors:Jana Neuwirthová, Pavel Smilek, Jitka Berkovcová, Jan Rottenberg, Rom Kostřica, Marian Hajdúch
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Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:EGFR head and neck cancers k-ras EGFR gene amplification tyrosine kinase mutation

We evaluated 45 samples from patients with locoregionally advanced head and neck cancers, treated by chemoradiotherapy / radiotherapy. We analysed variuos mutations in EGFR signal pathway in correlation with therapeutical response.