Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers
|Original title:||Mutations in EGFR signal pathway in correlation with response to treatment of head and neck cancers|
|Authors:||Jana Neuwirthová, Pavel Smilek, Jitka Berkovcová, Jan Rottenberg, Rom Kostřica, Marian Hajdúch|
|Field:||ORL, ophthalmology, stomatology|
|Type:||Article in Periodical|
|Keywords:||EGFR head and neck cancers k-ras EGFR gene amplification tyrosine kinase mutation|
We evaluated 45 samples from patients with locoregionally advanced head and neck cancers, treated by chemoradiotherapy / radiotherapy. We analysed variuos mutations in EGFR signal pathway in correlation with therapeutical response.