Publication details

 

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Basic information
Original title:Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer
Authors:Richard Salzman, Lukáš Pácal, Josef Tomandl, Kateřina Kaňková, Eva Tothova, Břetislav Gál, Rom Kostřica
Further information
Citation:SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA, Břetislav GÁL a Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. Anticancer Research, Greece: INT INST ANTICANCER RESEARCH, 2009, roč. 10/2009, č. 29, s. 4227-4231. ISSN 0250-7005.Export BibTeX
@article{869081,
author = {Salzman, Richard and Pácal, Lukáš and Tomandl, Josef and Kaňková, Kateřina and Tothova, Eva and Gál, Břetislav and Kostřica, Rom},
article_location = {Greece},
article_number = {29},
keywords = {head and neck carcinoma prognosis oxidative stress malondialdehyde},
language = {eng},
issn = {0250-7005},
journal = {Anticancer Research},
title = {Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer},
volume = {10/2009},
year = {2009}
}
Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:head and neck carcinoma prognosis oxidative stress malondialdehyde

There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).

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