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Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Basic information
Original title:Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer
Authors:Richard Salzman, Lukáš Pácal, Josef Tomandl, Kateřina Kaňková, Eva Tothova, Břetislav Gál, Rom Kostřica
Further information
Citation:SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA, Břetislav GÁL and Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. Anticancer Research, Greece: INT INST ANTICANCER RESEARCH, 2009, 10/2009, No 29, p. 4227-4231. ISSN 0250-7005.Export BibTeX
@article{869081,
author = {Salzman, Richard and Pácal, Lukáš and Tomandl, Josef and Kaňková, Kateřina and Tothova, Eva and Gál, Břetislav and Kostřica, Rom},
article_location = {Greece},
article_number = {29},
keywords = {head and neck carcinoma prognosis oxidative stress malondialdehyde},
language = {eng},
issn = {0250-7005},
journal = {Anticancer Research},
title = {Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer},
volume = {10/2009},
year = {2009}
}
Original language:English
Field:ORL, ophthalmology, stomatology
Type:Article in Periodical
Keywords:head and neck carcinoma prognosis oxidative stress malondialdehyde

There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).

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