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Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy

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Original title:Gain of 1q21 Is an Unfavorable Genetic Prognostic Factor for Multiple Myeloma Patients Treated with High-Dose Chemotherapy
Authors:Pavel Němec, Zuzana Zemanová, Henrieta Grešliková, Kyra Michalová, Hana Filková, Jana Tajtlová, Dana Králová, Renata Kupská, Jan Smetana, Marta Krejčí, Luděk Pour, Lenka Zahradová, Viera Sandecká, Zdeněk Adam, Tomáš Büchler, Ivan Špička, Evžen Gregora, Petr Kuglík, Roman Hájek
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Original language:English
Field:Oncology and hematology
Type:Article in Periodical
Keywords:Multiple myeloma; 1q21 Gain; Survival; Chromosomal aberrations; Fluorescein in situ hybridization

The prognostic significance of 1q21 gain, del(13)(q14), del(17)(p13), t(4;14)(p16.3;q32), and t(11;14)(q13;q32) detected by interphase fluorescein in situ hybridization (FISH) was studied in a cohort of 91 patients with newly diagnosed multiple myeloma (MM). 1q21 gain was detected in 37 of 91 patients (40.7%). In comparison with patients lacking 1q21 gain, patients with 1q21 gain had significantly shorter progression-free survival (PFS) (14.9 versus 27.4 months; P = .044) and worse 4-year overall survival (OS) (40.1% versus 76.2% of patients; P = <.001). PFS or OS were not influenced by the presence or absence of the other studied chromosomal abnormalities. Although the occurrence of 1q21 gain correlated with deletion of 13q14, the presence of 1q21 gain can be considered an independent prognostic factor, as no impact of del(13)(q14) as an isolated chromosomal abnormality on either PFS or OS has been observed. We conclude that 1q21 gain defines a prognostically unfavorable group of MM patients.

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