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Publication details

Neurotoxický, neuroprotektivní či neuroplastický účinek antipsychotik?

Further information
Citation:	KAŠPÁREK, Tomáš. Neurotoxický, neuroprotektivní či neuroplastický účinek antipsychotik? (Neurotoxic, neuroprotective, or neuroplastic effects of antipsychotics?). Česká a slovenská psychiatrie, Praha: ČLS JEP, 2010, vol. 106, No 1, p. 22-29. ISSN 1212-0383.Export BibTeX @article{875330, author = {Kašpárek, Tomáš}, article_location = {Praha}, article_number = {1}, keywords = {antipsychotics; neuropathology; schizophrenia; morphology}, language = {cze}, issn = {1212-0383}, journal = {Česká a slovenská psychiatrie}, title = {Neurotoxický, neuroprotektivní či neuroplastický účinek antipsychotik?}, volume = {106}, year = {2010} }
Original language:	Czech
Field:	Psychiatry, sexuology
Type:	Article in Periodical
Keywords:	antipsychotics; neuropathology; schizophrenia; morphology

Klíčovým rysem neuropatologie schizofrenie je redukce tloušťky kortexu daná redukcí neuropilu pyramidových buněk II. a III. kortikální vrstvy. Antipsychotika první generace jsou neurotoxická, II. generace antipsychotik podporuje neuroplastické procesy. Neexistují však důkazy o tom, že by zasahovala do neuropatologických dějů schizofrenie, tj. že indukovaná neuroplasticita opravdu koriguje patologii schizofrenie.

The key feature of the neuropathology of schizophrenia is the cortical thickness reduction due to the neuropil reduction of pyramidal neurons in II. and III. cortical layers. First-generation antipsychotics exert neurotoxic effect on brain morphology. The second generation of antipsychotics stimulates neuroplastic processes. There is, however, no evidence that they target the neuropathological changes in schizophrenia, that induced neuroplasticity in fact corrects the pathology of schizophrenia.

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