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Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review

Basic information
Original title:Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review
Authors:Miroslav Pohanka, J. Pejchal, Svatava Snopková, Kateřina Havlíčková, J.Z. Karasová, Pavel Boštík, J. Pikula
Further information
Citation:POHANKA, Miroslav, J. PEJCHAL, Svatava SNOPKOVÁ, Kateřina HAVLÍČKOVÁ, J.Z. KARASOVÁ, Pavel BOŠTÍK a J. PIKULA. Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review. Mini-reviews in medicinal chemistry, Sharjah: Betham Science Publ Ltd., 2012, roč. 12, č. 1, s. 35-43. ISSN 1389-5575.Export BibTeX
@article{975156,
author = {Pohanka, Miroslav and Pejchal, J. and Snopková, Svatava and Havlíčková, Kateřina and Karasová, J.Z. and Boštík, Pavel and Pikula, J.},
article_location = {Sharjah},
article_number = {1},
keywords = {Vitamin C; low molecular weight antioxidant; oxidative stress; inflammation; reactive oxygen species},
language = {eng},
issn = {1389-5575},
journal = {Mini-reviews in medicinal chemistry},
title = {Ascorbic Acid: An Old Player with a Broad Impact on Body Physiology Including Oxidative Stress Suppression and Immunomodulation: A Review},
volume = {12},
year = {2012}
}
Original language:English
Field:Epidemiology, infectious diseases and clinical immunology
Type:Article in Periodical
Keywords:Vitamin C; low molecular weight antioxidant; oxidative stress; inflammation; reactive oxygen species

Ascorbic acid is a low molecular weight antioxidant well known as anti-scorbut acting vitamin C in humans, primates and guinea pigs. This review summarizes basic data about ascorbic acid in its physiological action point of view. It is divided into biochemistry of ascorbic acid synthesis, mechanism of antioxidant action and participation in anabolism, pharmacokinetics and excretion, exogenous ascorbic acid immunomodulatory effect and participation in infectious diseases, impact on irradiation and intoxication pathogenesis, and supplementary demands. The primary intention was to consider ascorbic acid not only as an antioxidant but also as a chemical compound affecting multiple pathways with a potential beneficial impact in many diseases and processes in human body.