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Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

Basic information
Original title:Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
Authors:Petra Faltejsková, Andrej Bešše, Sabina Ševčíková, Lenka Kubiczková, Marek Svoboda, Jan Šmarda, Igor Kiss, Rostislav Vyzula, Ondřej Slabý
Further information
Citation:FALTEJSKOVÁ, Petra, Andrej BEŠŠE, Sabina ŠEVČÍKOVÁ, Lenka KUBICZKOVÁ, Marek SVOBODA, Jan ŠMARDA, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells (Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells). International Journal of Colorectal Disease, New York: Springer, 2012, vol. 27, No 11, p. 1401-1408. ISSN 0179-1958. doi:10.1007/s00384-012-1461-3.Export BibTeX
@article{979090,
author = {Faltejsková, Petra and Bešše, Andrej and Ševčíková, Sabina and Kubiczková, Lenka and Svoboda, Marek and Šmarda, Jan and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
article_location = {New York},
article_number = {11},
doi = {http://dx.doi.org/10.1007/s00384-012-1461-3},
keywords = {miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration},
language = {eng},
issn = {0179-1958},
journal = {International Journal of Colorectal Disease},
title = {Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells},
url = {http://link.springer.com/article/10.1007%2Fs00384-012-1461-3},
volume = {27},
year = {2012}
}
Original language:English
Field:Oncology and hematology
WWW:link to a new windowhttp://link.springer.com/article/10.1007%2Fs00384-012-1461-3
Type:Article in Periodical
Keywords:miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration

MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

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