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Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

Basic information
Original title:Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function
Authors:Jiří Jarkovský, Jiří Pařenica, Roman Miklík, Monika Pávková Goldbergová, Petr Kala, Lenka Malásková, Zdeňka Čermáková, Martin Poloczek, Miroslav Vytiska, Lenka Kubková, Kateřina Helánová, I. Parenicova, Simona Littnerová, L. Dostalova, P. Kubena, Anna Vašků, Jindřich Špinar
Further information
Citation:JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ a Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE, 2012, roč. 11, č. 1, s. 32-40. ISSN 2042-4884. doi:10.5083/ejcm.20424884.67.Export BibTeX
@article{980955,
author = {Jarkovský, Jiří and Pařenica, Jiří and Miklík, Roman and Pávková Goldbergová, Monika and Kala, Petr and Malásková, Lenka and Čermáková, Zdeňka and Poloczek, Martin and Vytiska, Miroslav and Kubková, Lenka and Helánová, Kateřina and Parenicova, I. and Littnerová, Simona and Dostalova, L. and Kubena, P. and Vašků, Anna and Špinar, Jindřich},
article_number = {1},
doi = {http://dx.doi.org/10.5083/ejcm.20424884.67},
keywords = {aortic pulse pressure; natriuretic peptides; marker},
language = {eng},
issn = {2042-4884},
journal = {EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE},
title = {Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function},
volume = {11},
year = {2012}
}
Original language:English
Field:Cardiovascular diseases incl. cardiosurgery
Type:Article in Periodical
Keywords:aortic pulse pressure; natriuretic peptides; marker

Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.

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