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Advances in patch clamp technique: towards higher quality and quantity

Basic information
Original title:Advances in patch clamp technique: towards higher quality and quantity
Author:Markéta Bébarová
Further information
Citation:BÉBAROVÁ, Markéta. Advances in patch clamp technique: towards higher quality and quantity. General physiology and biophysics, GENERAL PHYSIOL AND BIOPHYSICS, 2012, roč. 31, č. 2, s. 131-140. ISSN 0231-5882. doi:10.4149/gpb_2012_016.Export BibTeX
@article{987349,
author = {Bébarová, Markéta},
article_number = {2},
doi = {http://dx.doi.org/10.4149/gpb_2012_016},
keywords = {Action potential clamp; Dynamic clamp; Cell-type transforming clamp; High-resolution scanning patch clamp; Automated patch clamp},
language = {eng},
issn = {0231-5882},
journal = {General physiology and biophysics},
title = {Advances in patch clamp technique: towards higher quality and quantity},
volume = {31},
year = {2012}
}
Original language:English
Field:Physiology
Type:Article in Periodical
Keywords:Action potential clamp; Dynamic clamp; Cell-type transforming clamp; High-resolution scanning patch clamp; Automated patch clamp

The patch clamp technique, developed in late 1970s, started a new period of experimental cardiac electrophysiology enabling measurement of ionic currents on isolated cardiomyocytes down to the level of single channels. Since that time, the technique has been substantially improved by development of several upgraded modifications providing so far unavailable data (e.g. action potential clamp, dynamic clamp, high-resolution scanning patch clamp), or facilitating the patch clamp technique by increasing its efficiency (planar patch clamp, automated patch clamp). The current review summarizes the leading new patch clamp based techniques used in cardiac cellular electrophysiology, their principles and prominent related papers.

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