Faculty of Medicine (pouze anglicky)

The Faculty of Medicine was founded in 1919. The total number of students is about 4,500. The faculty offers the Master’s study programme of General Medicine that runs in both Czech and English languages and the Master’s programme of Dentistry. There are also Bachelor’s programmes available in Health Care and Nursing.

Contact information

link to a new windowwww.med.muni.cz
www.muni.cz/research

Kamenice 5
CZ-625 00 Brno
Czech Republic
Phone: +420 54949 1011
Fax: +420 542 213 996

research@med.muni.cz

Detailed information on R&D areas and projects:

 

Stem cell researchback

In recent years stem cells are subject of increasing scientific interest because of their potential utility in numerous biomedical applications. The most attractive applications include: transplantation to replace cell population destroyed by disease (cell therapy); testing of negative effects of chemical compounds such as toxicity, mutagenicity, and teratogenicity; discovery of bioactive substances – drugs; and modelling of human development and human diseases. The research is also focused to clinical application of mesenchymal stem cells for treatment of hemato-oncologic diseases.

Selected projects solved in this area:

 

Neurosciencesback

Neuroscience research comprises several fields of nervous system investigation. One of the aims is to study functions of the CNS as a model of mutually interconnected functional network under normal and pathological conditions, their plasticity and monitoring of therapy. Mechanisms of speech, writing, cognitive processing of afferent information, emotional and attention factors, working memory, decisional processes in self-paced as well as in cued tasks, including the motor tasks and motor control are investigated by a combination of methods of molecular genetic, neuropsychology, electrophysiological recordings, functional MR and MR spectroscopy, SPECT and PET. Experimental investigation of drug addiction, mechanisms of nervous system regeneration and neuropathic pain induction is further aim of neuroscience research.

Selected projects solved in this area:

 

Cell immunotherapyback

The research program is aimed to study immunostimulatory molecules and universal tumor antigens, identification of individual antigen-specific T cells and development of dendritic cell vaccine with high IL-12 production using autologous tumor cell lysate, e.g., renal cell carcinoma or glioblastoma.

Selected projects solved in this area:

 

Recombination and DNA repairback

DNA double-strand breaks (DSB) are among the most lethal forms of DNA damage. DSBs are induced by a large number of endogenous and exogenous agents, as genotoxic chemicals and ionizing radiation, or due to replication of damaged DNA as well as collapse of a replication fork. DSB can either be properly repaired, restoring genomic integrity, or miss-repaired resulting in cell death, genomic instability, and cancer. Our group focuses on mechanisms of DSB repair using multi-disciplinary approach (biochemical, structural, computational, genetic, and single-molecule).

Selected project solved in this area:

 

Cardiovascular researchback

The research program is aimed to development of new non-invasive methods of early diagnosis of cardiovascular diseases related with essential hypertension, diabetes mellitus and long-lasting injury of heart by side-effects of life-rescued medicaments. Experimental part of investigation is focused to study of electrochemical processes during cardiomyocyte excitation and contraction as well as to electric and mechanic consequences of heart signalization by sigma receptors.

Selected project solved in this area:

 

Bacterial genetics & genomicsback

Functional and comparative genomics research is focused on pathogenic treponemes and includes identification of treponemal gene functions and comparison of the genome structure of treponemes with different virulence potential. Whole genome DNA sequencing microarray-based genome comparisons, expression profiling and other relevant methods are employed. Molecular genetics lab studies molecular interactions between colicins and their receptor(s) and between colicins and their immunity proteins. These experiments will identify protein domains involved in colicin receptor binding and in colicin inactivation by its cognate immunity protein. Understanding of these protein-protein interactions is important for molecular engineering of bacteridical proteins.

Selected project solved in this area:

 

Oncologyback

Research is held in various areas such as pneumooncology, haematooncology, paediatric oncology, etc. Also, attention is paid to surgery that involves a wide field of specialised problems in digestive, vascular, and thoracic surgeries including benign and malignant diseases.

Selected project solved in this area:

 

Primary immunodeficiency diseasesback

The research in the field of immunopathology is focused mainly to pathogenesis and treatment possibilities in primary immunodeficiency diseases. Lymphocyte subpopulation abnormalities determination and the response to specific antigen on the cellular level are the main approaches used.

Selected project solved in this area:

 

Collaborative foreign entitiesback

  • CDC Centers for Disease Control and Prevention, Georgia [US]
  • Columbia University [US]    
  • IMP-IMBA Research Center [AT]   
  • INSERM, ADR Lyon [FR]     
  • Memorial Sloan-Kettering Cancer Center [US]    
  • New York University [US]
  • NIH Clinical Center, National Istitutes of Health [US]      
  • Rutgers University[US]     
  • Slovak Academy of Science [SK]  
  • Tampere University of Technology [FI]
  • Technical University of Denmark [DK]     
  • University of Bristol [UK]    
  • University of California, Davis [US]
  • University of Glasgow [UK] 
  • University of Kopenhagen [DK]     
  • University of Minnesota, Minneapolis [US]
  • University of Oxford [UK]
  • University of Sheffield [UK]
  • University of Texas Medical School at Houston, Texas [US]
  • University of Texas Southwestern Medical Center, Dallas [US]
  • Washington University [US]
  • Washington University School of Medicine, Missouri [US]
  • Yale University [US]