Informace o publikaci

Cognitive impairment and cortisol levels in first-episode schizophrenia patients

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HAVELKA David PŘIKRYLOVÁ KUČEROVÁ Hana PŘIKRYL Radovan ČEŠKOVÁ Eva

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Stress : The International Journal on the Biology of Stress
Fakulta / Pracoviště MU

Filozofická fakulta

Citace
www http://www.tandfonline.com/doi/full/10.1080/10253890.2016.1193146
Doi http://dx.doi.org/10.1080/10253890.2016.1193146
Obor Psychologie
Klíčová slova Cognitive impairment; dexamethasone suppression test; first-episode schizophrenia; memory functions; plasma afternoon cortisol levels; plasma post-dexamethasone cortisol levels
Popis Many modalities of cognition are affected in schizophrenia. The most common findings include dysfunctions of episodic and working memory and of executive functions. Although an inverse correlation between cortisol level and memory function has been proven, few studies have focused on the relationship between cortisol level and cognitive impairment in patients with schizophrenia. In an open, naturalistic, prospectivestudy, consecutively hospitalized males diagnosed with first-episode schizophrenia, hypothalamic–pituitary–adrenal axis activity (afternoon cortisol levels, post-dexamethasone cortisol levels) was evaluated before and at the end of acute treatment. Psychopathology was assessed using the positive and negative syndrome scale (PANSS). Cognitive functions (memory, attention, psychomotor, verbal fluency, and executive functions) were tested after symptom alleviation using a neurocognitive test battery. In the total sample (n=23), significant decreases in total PANSS score (including all subscales), afternoon cortisol levels, and post-dexamethasone cortisol levels occurred during the course of treatment. It was found that higher afternoon cortisol levels at the beginning of treatment were significantly related to impaired performance in memory functions. Afternoon cortisol levels were not significantly associated with other measured cognitive functions. No correlation was discovered between cognitive functions and post-dexamethasone cortisol levels. The determination of afternoon cortisol levels may serve to detect potential candidates for specific cognitive intervention immediately after the first psychotic breakthrough.
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