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Markers of oxidative stress in STEMI patients with acute heart failure.

Basic information
Original title:Markers of oxidative stress in STEMI patients with acute heart failure.
Authors:Marie Tomandlová, Josef Tomandl, Jiří Pařenica, Petr Kala, Martin Poloczek, Eva Táborská, Jindřich Špinar
Further information
Citation:TOMANDLOVÁ, Marie, Josef TOMANDL, Jiří PAŘENICA, Petr KALA, Martin POLOCZEK, Eva TÁBORSKÁ and Jindřich ŠPINAR. Markers of oxidative stress in STEMI patients with acute heart failure. In Europen Journal of Heart Failure Supplements. 2011. ISSN 1567-4215.Export BibTeX
@proceedings{945606,
author = {Tomandlová, Marie and Tomandl, Josef and Pařenica, Jiří and Kala, Petr and Poloczek, Martin and Táborská, Eva and Špinar, Jindřich},
booktitle = {Europen Journal of Heart Failure Supplements},
keywords = {oxidative stress; myocardial infarction; heart failure},
language = {eng},
title = {Markers of oxidative stress in STEMI patients with acute heart failure.},
url = {http://www.eurjhfsupp.oxfordjournals.org},
year = {2011}
}
Original language:English
Field:Biochemistry
WWW:link to a new windowhttp://www.eurjhfsupp.oxfordjournals.org
Type:Conference abstract
Keywords:oxidative stress; myocardial infarction; heart failure

In patients with myocardial infarction or heart failure oxidative stress may contribute to myocyte apoptosis, decrease nitric oxide bioavailability or have direct negative inotropic effect. The aim of the study was to determine levels of parameters of oxidative stress (malondialdehyde, TNFalfa) and antioxidants (vitamins A and E, uric acid) and their relation to the extent of myocardial infarction and heart failure in patients with STEMI. Cohort of 179 subjects consecutively admitted to the CCU (from 10/2005 to 10/2008) with first STEMI, treated by PCI. Both lipid peroxidation (MDA) and activated macrophages (TNFalfa) are involved in acute STEMI patients. Levels of vitamin A and E correspond with the extent of lipid peroxidation and negatively with macrophage activation, respectively, but endogenous antioxidant uric acid does not. Surprisingly, no effects of smoking or diabetes mellitus were observed on the evaluated parameters of oxidative stress.

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