Project details


Elucidating the role and molecular mechanism of Neuratin (NNAT) in neural induction (NEURALDEVESTEM)

Project Identification:2SGA2878
Project Period:4/2011 - 3/2013
Investor:link to a new windowSouth-Moravian Region
Programme / Project Type:SoMoPro - Incoming grants
MU Faculty/Unit:
Faculty of Medicine
MU Investigator:Assoc. Prof. Yuh-Man Wadeley

Our novel findings show Nnat initiates neural induction in mouse ES cells through increasing intracellular Ca2+ ([Ca2+]i) by antagonising Ca2+ -ATPase (Sarco/ Endoplasmic Reticulum Ca2+-ATPase, SERCA isoform 2, SERCA2) in the endoplasmic reticulum, which in turn increases the phosphorylation of Erk1/2 and inhibits the BMP4 pathway, leading to neural induction in conjunction with FGF/Erk pathway (Fig. 1) (2) (for more details, please see section 3.2). Based on this we propose that NNAT plays a similar role in hES cells.