Project details
Molecular pathophysiology of selected multigenic related to civilization diseases
| Project Identification: | VS96097 | ||||
| Project Period: | 7/1996 - 12/2000 | ||||
| Investor: |  Ministry of Education, Youth and Sports of the CR | ||||
| MU Faculty/Unit: |
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| Field: | EB - Genetics and molecular biology (E - Bio-science) EA - Morphological specializations and cytology (E - Bio-science) ED - Physiology (E - Bio-science) | ||||
| Publications/Results: | more | ||||
| Keywords: | genetics of multigenic diseases, candidate gene approach, case-control study, intermediate phenotypes, essential hypertension, late complications of diabetes mellitus, atopic diseases, metastatic growth, malignant tumors, genetic associations | ||||
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
