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Project details

Molecular pathophysiology of multigene diseases

Project Identification:	MSM 141100002
Project Period:	1/1999 - 1/2004
Investor:	Ministry of Education, Youth and Sports of the CR
Programme / Project Type:	Research Intents
MU Faculty/Unit:	Faculty of Medicine MU Investigator: Prof. MUDr. Jiří Vácha, DrSc.
Publications/Results:	more
Keywords:	Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.

Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).