Project details
New photoactivatable systems for biological studies
| Project Identification: | ME09021 | ||||
| Project Period: | 4/2009 - 12/2012 | ||||
| Investor: |  Ministry of Education, Youth and Sports of the CR | ||||
| MU Faculty/Unit: |
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| Field: | CH - Nuclear and quantum chemistry, photochemistry (C - Chemistry) CC - Organic chemistry (C - Chemistry) CF - Physical chemistry and theoretical chemistry (C - Chemistry) | ||||
| Publications/Results: | more | ||||
| Keywords: | Photochemistry | ||||
Photoactivatable compounds (also called caged compounds) are systems which, upon photoactivation, either (1) irreversibly release a species possessing desirable physical, chemical, or biological qualities, while the groups that are responsible for the photoprocess are referred to as photoremovable; or (2) reversibly induce physical or chemical changes in a system; in such cases, they are called photochemical switches and the process is usually photochromic (photochromism is a reversible chemical transformation, induced in one or both directions by the absorption of light, between two forms having different absorption spectra and other photophysical properties). Photoactivatable compounds are of a great interest in connection with biochemical and biological applications (e.g., photoregulations of proteins and enzyme activity, neurotransmitters, ATP, and Ca2+ delivery, or photoactivatable fluorophores), organic synthesis (e.g., photoremovable protecting groups; solid-phase synthesis; microarray fabrica
