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Mybs in mouse hair follicle development

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VESELÁ Barbora ŠVANDOVÁ Eva ŠMARDA Jan MATALOVÁ Eva

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Tissue and Cell
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www http://www.sciencedirect.com/science/journal/00408166
Doi http://dx.doi.org/10.1016/j.tice.2014.06.006
Obor Genetika a molekulární biologie
Klíčová slova Mybs; hair follicles; development; stem cells
Popis The Myb transcription factors are involved in essential cellular processes, such as cell proliferation, dif-ferentiation and cell death. Biological functions carried out by specific Myb proteins are distinct. Hairfollicles are ectodermal-derived organs with cycling character of the growth resulting from the pres-ence of somatic stem cells. In this study, we followed the expression of the Myb proteins in developinghair follicles and in the hair follicle stem cell niche by immunofluorescence staining. During hair follicledevelopment, B-Myb was present in a few cells located in the area of cell division; c-Myb was abun-dant postanally in dividing cells but also in keratinizing zone. In addition, c-Myb was also detected incells under the hair follicle bulge. These findings indicate possible involvement of c-Myb in regulation of activated stem cells leaving the niche.
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