Informace o publikaci

Current Status of Left Ventricular Assist Device Therapy

Autoři	ŠAJGALÍK Pavol GRUPPER Avishay EDWARDS Brook S. KUSHWAHA Sudhir S. STULAK John M. JOYCE David L. JOYCE Lyle D. DALY Richard C. KÁRA Tomáš SCHIRGER John A.
Rok publikování	2016
Druh	Článek v odborném periodiku
Časopis / Zdroj	Mayo Clinic Proceedings
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1016/j.mayocp.2016.05.002
Obor	Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova	MECHANICAL CIRCULATORY SUPPORT; ADVANCED HEART-FAILURE; DRUG ADMINISTRATION-APPROVAL; END-ORGAN FUNCTION; BODY-MASS INDEX; CONTINUOUS-FLOW; DESTINATION THERAPY; LONG-TERM; PATIENT SELECTION; INTERAGENCY REGISTRY
Popis	Congestive heart failure (HF) remains a serious burden in the Western World. Despite advances in pharmacotherapy and resynchronization, many patients have progression to end-stage HF. These patients may be candidates for heart transplant or left ventricular assist device (LVAD) therapy. Heart transplants are limited by organ shortages and in some cases by patient comorbidities; therefore, LVAD therapy is emerging as a strategy of bridge to transplant or as a destination therapy in patients ineligible for transplant. Patients initially ineligible for a transplant may, in certain cases, become eligible for transplant after physiologic improvement with LVAD therapy, and a small number of patients with an LVAD may have sufficient recovery of myocardial function to allow device explantation. This clinically oriented review will describe (1) the most frequently used pump types and aspects of the continuous-flow physiology and (2) the clinical indications for and the shift toward the use of LVADs in less sick patients with HF. Additionally, we review complications of LVAD therapy and project future directions in this field. We referred to the Interagency Registry for Mechanically Assisted Circulatory Support, landmark trials, and results from recently published studies as major sources in obtaining recent outcomes, and we searched for related published literature via PubMed. This review focuses primarily on clinical practice for primary care physicians and non-HF cardiologists in the United States.