Informace o publikaci

An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed nonHodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Autoři

LOBELLO Cosimo JANÍKOVÁ Andrea JANÍKOVÁ Andrea KŘEN Leoš HERMANOVÁ Markéta ŠPRLÁKOVÁ-PUKOVÁ Andrea KREJČÍ Jan POSPÍŠILOVÁ Šárka PYTLÍK Robert HAMOUZOVÁ Michaela BELADA David PROCHAZKA Vit DURAS Juraj MÓCIKOVÁ Heidi TRNĚNÝ Marek

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Cancer Research & Therapy
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://nobleresearch.org/Doi/10.14312/2052-4994.2017-13
Doi http://dx.doi.org/10.14312/2052-4994.2017-13
Klíčová slova cardiac lymphoma; anaplastic large cell lymphoma; ALK
Popis We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the same -approximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info