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Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance

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Original title:Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance
Authors:Zdeněk Ráčil, Iva Kocmanová, Martina Tošková, Lucie Burešová, Barbora Weinbergerová, Martina Lengerová, Monika Rolencová, Jana Winterová, Kristýna Hrnčířová, Pavlína Volfová, Jana Skřičková, Jiří Mayer
Further information
Citation:RÁČIL, Zdeněk, Iva KOCMANOVÁ, Martina TOŠKOVÁ, Lucie BUREŠOVÁ, Barbora WEINBERGEROVÁ, Martina LENGEROVÁ, Monika ROLENCOVÁ, Jana WINTEROVÁ, Kristýna HRNČÍŘOVÁ, Pavlína VOLFOVÁ, Jana SKŘIČKOVÁ and Jiří MAYER. Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance. International Journal of Infectious Diseases, Oxford: Elselvier, 2011, vol. 15, No 12, p. "e874"-"e881". ISSN 1201-9712. doi:10.1016/j.ijid.2011.09.011.Export BibTeX
@article{956937,
author = {Ráčil, Zdeněk and Kocmanová, Iva and Tošková, Martina and Burešová, Lucie and Weinbergerová, Barbora and Lengerová, Martina and Rolencová, Monika and Winterová, Jana and Hrnčířová, Kristýna and Volfová, Pavlína and Skřičková, Jana and Mayer, Jiří},
article_location = {Oxford},
article_number = {12},
doi = {http://dx.doi.org/10.1016/j.ijid.2011.09.011},
keywords = {galaktomanan; BAL; invazivní plicní aspergilóza; hematologická malignita},
language = {eng},
issn = {1201-9712},
journal = {International Journal of Infectious Diseases},
title = {Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance},
volume = {15},
year = {2011}
}
Original language:English
Field:Oncology and hematology
Type:Article in Periodical
Keywords:galaktomanan; BAL; invazivní plicní aspergilóza; hematologická malignita

We evaluated the performance of a galactomannan (GM) assay in bronchoalveolar lavage (BAL) fluid compared to serum samples for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological diseases. Results: Twenty-eight cases of IPA (11%) were diagnosed. The highest sensitivity (78.6%) with good specificity (98.6%) was obtained with a triple detection of GM in bronchial, alveolar, and serum samples. Neutropenia and antifungal therapy for only 24 h increased the sensitivity, while antifungal treatment for more than 2 days decreased assay performance.Conclusions: In contrast to recently published data, we found only moderate sensitivity, but high specificity and high positive predictive value of the detection of GM in BAL fluid.

 
 
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