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Nestin expression in high-grade osteosarcomas and its clinical significance

Basic information
Original title:Nestin expression in high-grade osteosarcomas and its clinical significance
Authors:Iva Zambo, Markéta Hermanová, Dagmar Adámková Krákorová, Peter Múdry, Karel Zitterbart, Michal Kýr, Karel Veselý, Jaroslav Štěrba, Renata Veselská
Further information
Citation:ZAMBO, Iva, Markéta HERMANOVÁ, Dagmar ADÁMKOVÁ KRÁKOROVÁ, Peter MÚDRY, Karel ZITTERBART, Michal KÝR, Karel VESELÝ, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Nestin expression in high-grade osteosarcomas and its clinical significance. Oncology Reports, Athens, Greece: Spandidos Publications Ltd., 2012, vol. 27, No 5, p. 1592-1598. ISSN 1021-335X. doi:10.3892/or.2012.1687.Export BibTeX
@article{984770,
author = {Zambo, Iva and Hermanová, Markéta and Adámková Krákorová, Dagmar and Múdry, Peter and Zitterbart, Karel and Kýr, Michal and Veselý, Karel and Štěrba, Jaroslav and Veselská, Renata},
article_location = {Athens, Greece},
article_number = {5},
doi = {http://dx.doi.org/10.3892/or.2012.1687},
keywords = {osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence},
language = {eng},
issn = {1021-335X},
journal = {Oncology Reports},
title = {Nestin expression in high-grade osteosarcomas and its clinical significance},
volume = {27},
year = {2012}
}
Original language:English
Field:Oncology and hematology
Type:Article in Periodical
Keywords:osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence

Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. High levels of nestin expression detected by immunofluorescence were associated with worse clinical outcomes. However, high levels of nestin expression detected by immunohistochemistry trended towards shorter OS and EFS but did not reach statistical significance. Nestin does not seem to represent a powerful prognostic marker for patients with high-grade osteosarcomas.

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